Product Description
Composition
Each g contains Tylvalosin (as Tylvalosin Tartrate INN) 625 mg.
Pharmacology
Tylvalosin is a new macrolide antibiotic having both bacteriostatic &
bactericidal activity. The additional benefit of Tylvalosin is that its metabolite,
3-AT has also antimicrobial activity. Tylvalosin can act intracellularly and
reaches relatively high intracellular concentration in phagocytic cells
(macrophages and neutrophils). The activity of macrophages can be
specifically increased and this may help the innate (nonspecific) immune
system. It inhibits protein synthesis of bacteria by binding with 50s
ribosomal subunit.
Indications
Poultry
Tylvalosin is indicated for the prevention & treatment of Mycoplasmosis,
necrotic enteritis & cholangiohepatitis. It is also effective against diseases
caused by Ornithobacterium rhinotracheale (ORT) in poultry.
Swine
Tylvalosin is indicated for the prevention & treatment of swine Enzootic
Pneumonia, Ileitis (Porcine Proliferative Encephalopathy), Swine Dysentery
& colitis.
Dosage & Administration
Poultry
MycoplasmosisTreatment: 1g/5 L drinking water (25 mg/kg body weight) daily for 3 days.
Prevention: 1g/5 L drinking water (25 mg/kg body weight) for first 3 days of
life. This may be followed by 1g/10 L drinking water (12.5 mg/kg body
weight) for 3-4 days during stress condition such as vaccination, change of
feed &/or for 3-4 days each month.
Necrotic EnteritisTreatment: 1g/5 L drinking water (25 mg/kg body weight) daily for 3-4 days.
Prevention: 1g/5 L drinking water (25 mg/kg body weight) for first 3-4 days
of life followed by 1g/10 L drinking water (12.5 mg/kg body weight) for 3-4
days starting 2 days before the expected outbreak.
Swine
5 mg/kg body weight daily for 5 days.
Contraindication
Animals hypersensitive to Tylvalosin are contraindicated.
Warning & Precaution
Good management and hygiene practices should be followed to reduce the
risk of re-infection.
Side Effects
Common side effects: Not known.
Rare side effects: Not known.
Use in pregnancy & lactation or Lay
It can be used in laying hen as it has been shown to have no adverse
effects on egg formation at the recommended dose. The use during
pregnancy & lactation in swine has not been established.
Drug Interaction
With medicine: Not known.
With food & others: Not known.
Overdose
No signs of intolerance have been observed in poultry species at up to 150
mg tylvalosin per kg body weight per day for 5 days.
Withdrawal Period
Poultry: Meat 2 days, Eggs- 0 (Zero) day.
Swine: 1-2 days.
Storage
Store below 300 C & dry place, protected from light.
Keep all medicines out of reach of children.
Packing
100 g in sachet.
