Magical 28® VET
Calcium Borogluconate & Magnesium Hypophosphite Hexahydrate Injection
DESCRIPTION
Magical 28® is a sterile injection containing Calcium, Magnesium and Phosphorus required for the treatment of milk fever and other Calcium, Magnesium & Phosphorus deficiencies of cattle, buffaloes, horse, sheep, goat, dog and cat.
COMPOSITION
Magical 28® injection contains Calcium Gluconate 28.00% (as Calcium Gluconate Injection grade BP), Magnesium Hypophosphite Hexahydrate 9.00% and Boric Acid BP 5.75%.
ACTIONS
Calcium: Calcium is an important ion, a major component of bones and teeth and is required for maintenance of a normal cardiac rhythm, blood clotting and initiation of neuromuscular and metabolic activities. In dairy cows, short-term hypocalcaemia almost always occurs at, or soon after parturition when mammary gland secretions become more than double. The cow’s requirement for Calcium also increases. This increased demand is not always balanced by an increase in the intestinal absorption of Calcium or by the mobilization of Calcium from bone, and the concentration of ionized Calcium in the plasma may fall. Hypocalcaemic recumbency (peri-parturient paresis, milk fever complex) in sheep and cattle is a metabolic disorder which occurs as a result of hypocalcaemia, often complicated by concurrent hypophosphataemia and sometimes complicated by concurrent hypomagnesaemia. Calcium therapy is provided to correct the immediate imbalance to allow time for the homoeostatic mechanisms to adapt. An almost immediate and dramatic response follows after intravenous infusion of Calcium in all species. In ruminants, Calcium is administered by slow intravenous infusion while monitoring the heart rate and rhythm and it can be administered by subcutaneous injection behind the shoulder in two divided sites.
Magnesium: Magnesium is an essential electrolyte, a co-factor in numerous enzyme systems and involved in phosphate transfer, muscle contractilities and neuronal transmission. Magnesium deficiency may occur in ruminants on lush pasture (Grass staggers) associated with heavy fertilizer application containing Nitrogen and Potash. Hypomagnesaemia may also occur in out wintered cows exposed to adverse weather conditions. Hypomagnesaemia may be a cause of sudden death in young suckled beef calves. Acute Magnesium deficiency is more commonly seen in beef cows during early lactation. Affected cattle become ataxic and excitable and collapses with tetanic convulsions of the limbs and neck. Chronic Magnesium deficiency may be associated with a decreased appetite and a reduction in milk yield. Hypomagnesaemia is often encountered in dry cows in herds with a high prevalence of milk fever (Hypocalcaemia). Hypomagnesaemic tetany
(Grass tetany/Lactation tetany) is a metabolic disorder which occurs as a result of hypomagnesaemia, usually complicated by hypoglycaemia and sometimes complicated by concurrent hypophosphataemia. Treatment with mixed solutions of Calcium, Phosphorus and Magnesium is often effective and the therapeutic effect of parenteral supplementation in cases of hypomagnesaemia is temporary and dietary supplementation should be started.
Phosphorus: Phosphorus is a key component in energy and protein metabolism and also is a structural part of bone. Hypophosphataemia may occur in association with parturient paresis in dairy cows but specific supplementation is not usually required. Phosphorus deficiency in the lactating cow has been associated with the development of post-parturient haemoglobinuria after the onset of acute haemolysis. More commonly, Phosphorus deficiency causes chronic hypophosphataemia, which may result in skeletal defects, lameness and low milk production. Phosphorus containing compounds may be used if animals fail to respond to Calcium therapy for parturient paresis. Chronic hypophosphataemia may occur in ruminants.
Indications & Usages
Magical 28® injection is indicated for the treatment of hypocalcaemia, hypomagnesaemia,
hypophosphataemia and also indicated in the following conditions:
1. Milk fever (Parturient paresis)
2. Milk fever complex (Peri-parturient paresis)
3. Lactation tetany
4. Hypocalcaemic condition associated with late gestation or early lactation
5. Sternal recumbency (S bend of neck)
6. Hypomagnesaemic tetany (grass tetany)
7. Transit paresis/transit tetany
8. Muscle tremors & stiff gait
9. Ketosis in ruminants
10. General debility due to parasitic infestations
DOSAGE & ADMINISTRATION
Magical 28® Injection is to be administered through subcutaneous and/or intravenous route (slowly for intravenous route). Magical 28® Injection is a supersaturated solution which is
prone to precipitation. The precipitate, if present, may be dissolved by warming the bottle to around 80 °C using warm bath, with occasional agitation, until the solution becomes clear (approximately two hours). Shake vigorously. Allow to cool to normal body temperature before administration. The solution should not be used if the precipitate remains after following the above procedure.
Cattle/Buffalo/ Calves/Sheep/Goat
0.5-1.0 mL per kg body weight by subcutaneous and/or slow intravenous route. Half of the dose can be given to effect by slow intravenous injection (10-20 minutes) and the remaining half by subcutaneous injection, or the full dose can be administered by subcutaneous injection. Injection may be repeated in several hours until there is evidence of improvement.
Oral route: 10 mL per liter of drinking water.
Duration of treatment: 2 to 3 consecutive days.
Or, as per direction of registered Veterinarian/ Consultant.
WITHDRAWAL PERIOD
Meat : 0 day, Milk : 0 day.
CONTRAINDICATIONS
Do not use in hypermagnesaemic animals. The product should not be given by the intravenous route in toxaemic animals.
PRECAUTIONS
Although IV administration is often preferred route and is being used, caution must be taken to monitor cardinal signs of the treated animal, particularly the cardiac rhythm. Calcium is cardiotoxic; therefore, Calcium containing solutions should be administered slowly (10-20 min) while cardiac auscultation is performed. If severe dysrhythmias or bradycardia develop, administration should be stopped until the heart rhythm returns to normal. Endotoxic animals are especially prone to dysrhythmias caused by IV Calcium therapy.
SIDE EFFECTS
Untoward cardiac or respiratory symptoms may appear during administration. If such symptoms appear, reduce the rate of injection or discontinue altogether to restore normal function.
STORAGE CONDITION
Do not store above 30 °C. Keep away from light and wet place. Keep out of reach of the children.
PRESENTATION
Magical 28® IV/SC Injection (500 mL): Each carton contains 1 bottle of 500 mL Calcium Borogluconate Injection with Magnesium Hypophosphite Hexahydrate. Each 100 mL contains Calcium Gluconate for Injection BP equivalent to Calcium Gluconate 28.00 g, Magnesium Hypophosphite Hexahydrate 9.00 g and Boric acid BP 5.75 g.
Magical 28® IV/SC Injection (250 mL): Each carton contains 1 bottle of 250 mL Calcium
Borogluconate Injection with Magnesium Hypophosphite Hexahydrate. Each 100 mL contains Calcium Gluconate for Injection BP equivalent to Calcium Gluconate 28.00 g, Magnesium Hypophosphite Hexahydrate 9.00 g and Boric acid BP 5.75 g.
Magical 28® IV/SC Injection (100 mL): Each carton contains 1 bottle of 100 mL Calcium Borogluconate Injection with Magnesium Hypophosphite Hexahydrate. Each 100 mL contains Calcium Gluconate for Injection BP equivalent to Calcium Gluconate 28.00 g, Magnesium Hypophosphite Hexahydrate 9.00 g and Boric acid BP 5.75 g.
