Composition
Each bolus contains
Triclabendazole BP 900 mg &
Levamisole Hydrochloride BP
equivalent to Levamisole 600 mg
Mode of action
Doubledex™ 1/2 Yet bolus contains two ideal anthelmintics like
Triclabendazole & Levamisole. Triclabendazole acts against mature and
immature flukes specially against liver flukes (Fascioliosis). It binds to the
beta tubulin of the parasites and blocks polymerization of tubulin into
microtubules. The process damages the integrity and transport functions of
cells within the parasite and ultimately the parasite dies.
Levamisole is an ideal broad spectrum anthelmintic that acts against
respiratory and intestinal round worms. It causes lysis of worms by
neuromuscular paralysis. Moreover, it acts as an immunomodulator.
Indication
Doubledex™ 1/, Vet bolus is a broad spectrum anthelmintic, effective
against trematode & nematode worms of cattle, buffalo, sheep/goat etc.
Doubledax™ 1/, Vet bolus is used for the treatment of acute, sub acute and
chronic Fascioliasis (infestation of trematodes) caused by Fasciola gigantica
& F. hepatica. Doubledex™ '/, Vet bolus is also used against major stomach,
intestine and respiratory nematodes of ruminants, such as
« Haemonchus spp. ° Ostertagia spp. ° Cooperia spp.
* Trichostrongylus spp. ¢ Bunostomum spp. ° Esophagostomum spp.
© Trichuris spp. * Dictyocaulus spp.
Dosage & Administration
1 Doubledex™ 1/, Vet bolus per 41-75 kg body weight or 19.5 mg per kg
body weight or as per following schedule:
Body weight (Kg) - No. of bolus
21-40 - 1/2 Bolus
41-75 - 1 Bolus
76-150 - 2 Bali
151-225 - 3 Boli
226-300 - 4 Boli
301-375 - 5 Boli
Doubledex™ 1/2 Vet bolus can be administered orally through water or by
Mixing with any feed (e.g. with molasses or by wrapping in a banana leat}
and feeding to the animal.
Or, as per direction of registered veterinarian / consultant.
Contraindication
Doubledex™ 1/, Vet bolus is contraindicated in animals hypersensitive to
active ingredients.
Side effect
Doubledex™ 1/, Vet bolus is well tolerated in livestock. At the recommended
doses there is no side effect.
Drug Interactions
This combination should not be used with Pyrantel, Morantel and
Diethylcarbamazine.
Over dosage
Triclabendazole 16 times and Levamisole 3 times more safe than the
recommended dosages.
Withdrawal period
Milk: 10 days; Meat: 28 days
Uses in pregnancy and lactation
There is no effect on pregnant animals if given in recommended dosage.
Doubledex™ 1/, Vet bolus has no embryonic or teratogenic effect reported
in fetus.
Precaution
The animal should be given adequate fluid during and after therapy.
Storage Condition
Store at or below 25 °C temperature. Keep away from light and wet place.
Keep out of reach of children.
Packaging
Doubledex™ 1/, Vet Bolus: Box containing 5 strips of 4 boli each. Each bolus
contains Triclabendazole BP 900 mg and Levamisole Hydrochloride BP
equivalent to Levamisole 600 mg.
